A Career AT Orphazyme

Orphazyme is a development stage biopharmaceutical company. Our highly motivated and talented team of professionals is dedicated to the development of innovative therapeutic approaches to severe diseases, and cooperates with the research community worldwide.

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Current VacancIES

Science Writer

Are you our new Science Writer? This is your opportunity to join a dedicated team of professionals and become an important part of the research department of a progressive and innovative biopharmaceutical company. Orphazyme A/S develops paradigm-changing drugs for the treatment of severe, debilitating neurodegenerative and neuromuscular diseases such as amyotrophic lateral sclerosis (ALS), sporadic inclusion body myositis (sIBM), and lysosomal storage disorders (LSDs).

We are seeking a Science Writer who can lead our soft-funding activities and support our scientific communication towards both professional and lay audiences.

Your tasks:
- Leading our soft-funding activities
- Writing scientific articles for publication in top academic journals
- Reading and researching specialist media and literature for internal strategic reporting
- Being responsible for the scientific integrity of our website
- Designing and developing scientific material for meetings and conferences

Profile:
- You have excellent communication skills and are fluent in English
- You have a background in Biochemistry, Pharmacology, Biotechnology, Molecular Biology, or similar
- You have extensive experience in writing grant applications
- You have experience with journalism and scientific communication

We offer
A highly dynamic and rewarding workplace with dedicated colleagues and a strong sense of purpose. We are looking for a new colleague to join our team on the journey towards bringing life-changing therapies to patients who have no satisfactory treatment options available today.

Application
Please apply by sending an email marked “Science Writer” with your application and CV to career@orphazyme.com. If you have questions about the position, you are welcome to contact Senior Science Manager, Nikolaj H. T. Petersen, via email at nhtp@orphazyme.com.

Deadline
October 31, 2018.

We encourage anyone interested in a job to apply, irrespective of gender, age, race, religion, or ethnicity.

Mass Spectrometry Specialist

Are you our new Mass Spectroscopy Specialist? This is your opportunity to join a dedicated team of professionals and become an important part of the research department of a progressive and innovative biopharmaceutical company. Orphazyme A/S develops paradigm-changing drugs for the treatment of severe, debilitating neurodegenerative and neuromuscular diseases such as amyotrophic lateral sclerosis (ALS), sporadic inclusion body myositis (sIBM), and lysosomal storage disorders (LSDs).

We seek an experienced scientist who can help us establish our new Mass Spectroscopy core facility, which will be an integrated part of our organization. 

Your tasks:
- Be responsible for the setup of and running our MS core facility
- Implement LC-MS spectrometry instrumentation
- Develop and validate LC-MS analysis for small molecules and their metabolites
- Implement LC-MS analytical methods for various lipid species
- Participate and contribute to research and development meetings

Profile:
- You hold a PhD in Biochemistry, Pharmacology, Biotechnology, Engineering, or similar
- You have in-depth practical and theoretical knowledge of LC-MS
- You have experience from assay development and validation
- You have strong knowledge in medicinal chemistry
- You have experience with the biotech or pharmaceutical industry
- You have excellent communication skills and are fluent in English

We offer
A highly dynamic and rewarding workplace with dedicated colleagues and a strong sense of purpose. We are looking for a new colleague to join our team on the journey towards bringing life-changing therapies to patients who have no satisfactory treatment options today.

Application
Please apply by sending an email marked “Mass Spectrometry Specialist” with your application and CV to career@orphazyme.com. If you have questions about the position, you are welcome to contact Director of Drug Discovery, Søren Neve, via email at sne@orphazyme.com.

Deadline
October 31, 2018.

We encourage anyone interested in a job to apply, irrespective of gender, age, race, religion, or ethnicity.

Medical Writer

Are you our new Medical Writer in a busy and ambitious working environment? This is your opportunity to join a dedicated team of professionals and become an important part of the Clinical Development staff of a progressive and innovative biopharmaceutical company.

Orphazyme is a listed biotech company based in Copenhagen. We develop new treatment options for orphan protein-misfolding diseases (lysosomal storage and protein-aggregation diseases). Concurrently, we are expanding within medical writing and therefore, we seek a Medical Writer to support our medical writing activities in our projects.

Your tasks:

- Preparation or oversight of regulatory clinical documents (e.g. Clinical Trial Protocols/Reports, Investigator’s Brochures, responses to authorities, Clinical Summaries and Overviews)
- Planning and coordination of activities in a cross-functional setting
- Medical writing support to various regulatory and scientific documents
- Review of clinical trial documents e.g. Clinical Development Plans, Statistical Analysis Plans (SAPs), protocols, and protocol amendments
- Support to other functional areas on communication best practices 

Profile:

- You have at least 3 years’ experience as a Medical Writer
- You have a university degree within Natural Sciences incl. skills within scientific research methods.
- You have the ability to drive, manage and write concise and targeted regulatory, scientific documents in collaboration with many stakeholders
- You have analytical skills and the ability to work with large amounts of information
- You are structured with an eye for detail
- You are self-driven and can work independently
- You have excellent communication skills and are fluent in English

We can offer you:

A small company in development with an exciting pipeline and a collaborative working environment with possibility to influence your own tasks and shape Medical Writing as a relatively new functional area in the company.

Application

Please apply by sending an email marked “Medical Writer” with your application and CV to career@orphazyme.com. If you have questions about the position, you are welcome to contact Lead Medical Writer, Signe Mølhøj at +45 3143 0012 or VP Clinical Operations, Dorthe Grønnegaard Mejer at +45 6122 1795.

Deadline

September 07, 2018.

We encourage anyone interested in the job to apply, irrespective of gender, age, race, religion, or ethnicity.

Director, US Medical Affairs

Position Description
Orphazyme US, Inc. is based in Newton, MA and is a wholly-owned subsidiary of Orphazyme A/S, headquartered in Copenhagen, Denmark. Orphazyme, founded in 2009, is a biopharmaceutical company focused on bringing novel treatments to patients living with life-threatening or debilitating rare diseases. Our research focuses on developing therapies for diseases caused by misfolding of proteins and lysosomal dysfunction. Arimoclomol, the company’s lead candidate, is in clinical development for four orphan diseases: Niemann-Pick disease Type C, Gaucher disease, sporadic Inclusion Body Myositis, and Amyotrophic Lateral Sclerosis. The Denmark-based company is listed on Nasdaq Copenhagen (ORPHA.CO). For more information, please visit www.orphazyme.com.  

Position Summary
The Director, US Medical Affairs will at first report to the CMO and be responsible for defining, developing the medical affairs strategy, and executing the tactical activities for neuromuscular and LSD/metabolic disease areas. The ideal candidate will be a highly self-motivated, collaborative, scientifically-oriented, and accomplished Medical Affairs leader with a flexible, hands-on and team-oriented style. They will provide medical guidance and leadership for the US consisting of medical communications, medical training, and KOL and payer engagement. Key activities will include: Establishing the medical strategy for multiple indication programs, lead execution of relevant medical affairs activities, forging strong relationships with key opinion leaders, supporting payer-related activities, compliantly support pre-commercial activities, and patient advocacy initiatives. The position will be based in the greater Boston area.

Roles and Responsibilities

• Lead strategy development and execution of medical affairs activities in the US, including medical and payer advisory boards, medical education initiatives, publications planning, diagnostic programs, congress activities, and payer interactions

• Communicate medical information and key findings externally and within the company

• Maintain high level of scientific and medical expertise in neuromuscular and LSD/metabolic diseases, serve as key medical resource in the diagnosis, treatment and management of targeted disease areas and associated products

• Hire and manage the US Medical Affairs team including Rare Disease Medical Liaisons

• Provide medical expertise to the commercial organization to compliantly assist in the development and execution of commercial activities, including training

• Serve as the medical reviewer for abstracts, publications, disease-related and product-related promotional materials, and non-promotional scientific materials, including reimbursement dossiers and payer materials

• Forge strong relationships with key opinion leaders and treaters

• Initiate and advance collaborations with health care professionals, researchers, payers, patient advocacy organizations

• Create and lead the execution of medical symposia

Requirements and Qualifications

• Will thrive in a fast-paced, changing environment with limited structure that requires flexibility, resourcefulness, being efficient, and communicating remotely

• At least 7 years in biopharmaceutical industry with at least 3 years in Medical Affairs

• MD or PharmD with a degree  

• Experience working in rare diseases and in start-up environment highly preferred

• Medical specialty training optimally in pediatric or adult neurology or relevant drug development experience within the field of pediatric and adult neurology

• Proven inspiring leadership and people management experience

• Able to work both independently and as a member of an integrated, interdisciplinary team in being accountable for carrying out assigned responsibilities

• Articulate in oral, presenting and writing skills, with a demonstrated ability to communicate well with others at varying professional levels, especially medical

• Able to effectively present information and respond to questions from groups of managers, clients, customers, and the general public

• Able to think creatively, analyze data, efficiently to define problems, develop solutions, and draw valid conclusions

• Track record of forming compliant partnerships with commercial colleagues

• Is responsive and approaches work with a sense of urgency

• Demonstrates genuine compassion and passion for patients and families

• Willing and able to travel up to 40% as needed, including some weekends

• Willing to work from home at first until a US office is opened  

To apply, please send your CV and application to mailto:career@orphazyme.com, att.: Chief Commercial Officer, Paul Merrigan. 

We encourage anyone interested in the job to apply, irrespective of gender, age, race, religion, or ethnicity.

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