MAJOR SHAREHOLDER ANNOUNCEMENT

Copenhagen, July 6, 2018 – Orphazyme A/S (the “Company”), a biopharmaceutical company dedicated to developing treatments for patients living with rare diseases, hereby announces the receipt of notification pursuant to Section 38 of the Danish Capital Markets Act from Danske Bank A/S that its indirect shareholding in the Company is 1,029,081 shares corresponding to 3.28% of the share capital in the Company and that Danske Bank A/S indirectly has control over 5.16% of the voting rights in the Company.

ORPHAZYME PRESENTS AT 2018 PARSEGHIAN SCIENTIFIC CONFERENCE FOR NIEMANN-PICK TYPE C RESEARCH

Copenhagen, June 4, 2018 – Orphazyme A/S, a biopharmaceutical company dedicated to developing treatments for patients living with rare diseases, today announced that Orphazyme is presenting preclinical, clinical, and novel biomarker data on Niemann-Pick disease Type C (NPC) at the 2018 Parseghian Scientific Conference for Niemann-Pick Type C Research in Tucson, Arizona, USA on June 2-4, 2018. 

ORPHAZYME ANNOUNCES ESTABLISHMENT OF US SUBSIDIARY IN MASSACHUSETTS

Copenhagen, April 17, 2018 – Orphazyme A/S, a biopharmaceutical company dedicated to developing treatments for patients living with rare diseases, today announced the creation of a US subsidiary, based in Newton, Massachusetts. The subsidiary is named Orphazyme US, Inc., and will directly support the US market to establish closer relationships with the medical, patient, and financial communities as the company expands its development program and global reach. The company also announced that Paul Merrigan will head Orphazyme US, Inc. as the US President in addition to his responsibilities as Chief Commercial Officer.