REPORTING OF TRANSACTIONS IN ORPHAZYME'S SHARES MADE BY PERSONS DISCHARGING MANAGERIAL RESPONSIBILITIES

Copenhagen, Denmark, March 8, 2019 – Pursuant to the Market Abuse Regulation article 19, Orphazyme A/S, CVR no. 32266355 (“Orphazyme”), hereby notifies receipt of information of the following transactions in Orphazyme’s shares by persons discharging managerial responsibilities in Orphazyme:

1 Details of the Reporting Person / Closely Associated Person

a) Name

Bo Jesper Hansen

2 Reason for the notification

a) Position/status

Member of the Board of Directors

b) Initial notification/Amendment

Initial notification

3 Details of the Company, emission allowance market participant, auction platform, auctioneer or auction monitor

a) Name

Orphazyme A/S

b) LEI code

54930025OZD2GGSQ7L42

4 Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each type of transaction; (iii) each date; and (iv) each place where transactions have been conducted

a) Description of the financial instrument, type of instrument and identification code

Shares

ISIN DK0060910917

b) Nature of the transaction

Purchase of shares

c) Price(s) and volume(s)

Price (s)

Volume (s)

DKK 46.90

2400.00

DKK 46.90

436.00

DKK 46.90

700.00

DKK 46.90

913.00

DKK 46.90

402.00

DKK 46.90

8862.00

DKK 46.90

700.00

DKK 46.90

168.00

DKK 47.00

34.00

DKK 47.00

267.00

DKK 47.00

214.00

DKK 47.00

387.00

DKK 47.00

88.00

DKK 47.00

230.00

DKK 47.00

294.00

DKK 47.00

305.00

DKK 47.00

267.00

DKK 47.00

353.00

DKK 47.00

487.00

DKK 47.00

407.00

DKK 47.00

267.00

DKK 47.00

339.00

DKK 47.00

267.00

DKK 47.00

338.00

DKK 47.00

267.00

DKK 47.00

354.00

DKK 47.35

207.00

DKK 47.50

357.00

DKK 47.50

790.00

d) Aggregated information

- Aggregated volume

- Price

Aggregated volume: 21,100

Price: DKK 46.96

e) Date of the transaction

2019-03-07 – between 11:00 and 16:00 UTC-time

f) Place of the transaction

Nasdaq Copenhagen A/S - XCSE